一个新霉素基因座替换了181个核苷酸,包括1号内含子的289个,以及2到4号外显子和4号内含子的32个。骨髓巨噬细胞的RNANorthern印迹分析证实了正常转录本的缺失,但产生了含有5号外显子的转录本。未检测到白三烯C4。(来源:J:87909)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入,基因内删除
--
1
1
24

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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