Del(6Vmn1r40-Aldh1l1)1Anl

This mutation is a 841,250 bp deletion on chromosome 6, with one breakpoint within the Aldh1l1 gene. This deletion removes all but the last two exons of the Aldh1l1 gene, the entire 5 flanking genomic sequence (putative promoter region), as well as at le ast 27 other upstream genes (J:134595). Neither Aldh1l1 mRNA nor protein is detectable in mutant mice. No no detectable urocanase activity is seen in homozygous mutant mice. (J:21726, J:72944, J:134595)