Exon 1被通过同源重组插入了诺美西林选择标记 cassette,用 Western blot 在大脑、脊髓和坐骨神经样本中对纯合突变小鼠的蛋白质检测未发现。(来源:J:87070)
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Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis of brain, spinal cord, and sciatic nerve samples. (J:87070)