将含有lacZ和neo的盒式载体通过同源重组插入了内源性位置。插入发生在起始密码子下游10个密码子的位置,这导致了两个编码N端部分的外显子的序列被删除。通过对肝脏和胃组织中提取的RNA进行Northern blot分析,未在纯合突变小鼠中检测到正常转录本。(来源:J:87066)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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