从ES细胞中通过同源重组,2到11号外显子被删除,并被抗氨苄青霉素抗性基因 cassette 替换。RT-PCR结果显示,纯合突变小鼠的整个大脑和睾丸中没有mRNA,而野生型小鼠得到了预期的带型。(来源:J:88199)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
2
22

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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