在孔-S6域含有的外显子上游插入了loxP位点,同时下游引入了含floxed Neo抗性基因的载体。通过在靶向的ES细胞中短暂表达克里格瑞重组酶,筛选出loxP位点分隔的孔-S6外显子被剔除,保留Neo抗性基因的细胞。(来源:J:86763)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv
Targeted
插入
--
1
8
10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部