包含一个带有floxed neo cassette的靶向载体,后面跟着小鼠Notch1序列片段和GFP,被插入到了内源性位置。删除floxed neo cassette会导致Notch1序列的表达,该序列编码NOTCH1的细胞内部分(氨基酸1749-2293),但不包含C端的PEST区域。绿色荧光蛋白(GFP)序列前有内源启动子(IRES)。(来源:J:86975)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S4/SvJaeSor
Targeted
插入
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227

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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