一段包含Mbd4的exons 1、2和3,以及Ift122的exon 1的基因组片段,通过同源重组的方式插入了诺卡因选择标记。被删除区域编码了全部的5-methylcytosine结合位点和一部分催化区域。RT-PCR结果显示,纯合MEFs中这两基因均未表达。(来源:J:86981, J:143544)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
Insertion, Intergenic deletion
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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