这个转基因构建包含了由大鼠脂肪酸结合蛋白启动子驱动的鼠 cyclin D1 基因。转基因小鼠在肝和小肠上皮细胞,以及结肠中过量表达 cyclin D1,而在肾脏中的表达量较低。这个品系的转基因拷贝数是F2品系的20倍,而F2品系自身也含有多个转基因拷贝。(来源:J:70394)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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插入
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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