在起始密码子下游的exon 1位置插入了新霉素选择性 cassette。通过对腺垂体组织的免疫组化分析,发现纯合突变小鼠中无蛋白表达。该等位基因产生功能蛋白的缺失,通过流式细胞术分析脾细胞进一步得到了证实(来源:J:87191)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
--
11

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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