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中文
在原位通过同源重组靶向载体将5个点突变工程插入。每个突变都导致了错义突变，去除了参与PI3-K、RasGAP、SHP-2和PLC-gamma信号传导的酪氨酸残基。第739、750、770和1008位的酪氨酸被替换为苯丙氨酸，第1020位的酪氨酸替换为异亮氨酸。保留了 intron 16 中的一个loxP位点。（来源：J:86542）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
