Rag1编码序列被替换成一段截短的核心Rag-1序列,后面跟着一个floxed的诺卡因抗性基因。随后,通过转染基于质粒的Cre重组酶,对靶向的ES细胞去除了诺卡因基因。核心Rag1的表达水平与完整蛋白相当。(来源:J:86464)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入
--
1
7
35

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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