Igh-J^{tm1(VDJ-VI10)Zbz}

The endogenous DQ52 and all four heavy chain J elements were replaced by the rearranged heavy chain VDJ region from VI10 (for a VSV-IND-neutralizing antibody) and a floxed neomycin resistance cassette. The neomycin cassette was removed in vivo by breeding to Cre deleter mice. Between 10 and 15% of B cells express this allele. (J:86411)