Camkk2^tm1Kpg

Exon 5 was removed via cre mediated recombination of a single loxP site in intron 4 and the 3' loxP site of a floxed neo cassette in intron 5. The deletion of exon 5 results in the removal of sequence encoding part of the catalytic domain common to all CaM kinase kinase beta isoforms and putatively generates a frameshift mutation that leads to a premature stop codon. Protein was undetected in the forebrain and cerebellum of homozygous mutant mice by homologous recombination. (J:86370)