编码孔区、两个跨膜域和环状核苷酸结合区域的外显子被替换成含tau-lacZ的 cassette。靶向载体中包含的含部分缺失胸苷激酶基因和抗氨苄青霉素基因的flanked区域,通过Cre介导的重组被剔除。杂合突变的嗅觉受体神经元的原位杂交未检测到转录物。(来源:J:83225)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count