编码孔区、两个跨膜域和环状核苷酸结合区域的外显子被替换成含tau-lacZ的 cassette。靶向载体中包含的含部分缺失胸苷激酶基因和抗氨苄青霉素基因的flanked区域,通过Cre介导的重组被剔除。杂合突变的嗅觉受体神经元的原位杂交未检测到转录物。(来源:J:83225)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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