Drd2^{tm1(IL2RA)Koba}

The human IL2RA gene was inserted into exon 2 of the endogenous locus. Thet targeting construct included a polyadenylation signal and neo gene immediately downstream of IL2RA. Treatment of mutant mice with a recombinant immunotoxin consisting of the variable regions of the anti-IL2RA monoclonal antibody fused to a bacterial exotoxin results in the specific ablation of cells expressing IL2RA via the Drd2 promoter. (J:85929)