内源性位点通过随机插入一个包含Splice接受器和β-geo以及polyadenylation信号的基因陷阱载体,插入到了编码第三Ig区段的第八外显子中,导致了失活。测序结果显示,载体插入点下游14个密码子位置出现了终止密码子。在纯合突变小鼠的肾提取物中,通过Western blot分析未检测到蛋白质表达。(来源:J:85162)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
基因捕获载体的插入
--
1
5
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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