这个基因的Exon 1和VpreB1整个基因被替换成由loxP位点包被的诺卡因抗性基因。Northern blot分析未检测到该基因的mRNA转录本,但通过PCR可以检测到少量含有切片的Exons 2和3的片段。这个mRNA不预测会产生蛋白质。所有mRNA产物可以通过Cre介导的诺卡因插入消除,但这并未对观察到的表型产生最终影响。(来源:J:76947)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intergenic deletion
--
1
3
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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