将含有lacZ和neo的磁带通过同源重组插入到了exon 1的起始密码子位置。这次插入删除了exon 1的编码区域,该区域编码了15个N端氨基酸。通过同源突变心脏组织的 Western blot 分析,未检测到内源性蛋白质。(来源:J:85181)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
8
27

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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