Exons 14和15,它们共同编码IIS5跨膜段和重复II中的孔,周围有loxP位点,随后在体外通过Cre介导的重组被剔除,然后传给下一代。尽管RT-PCR检测到13号外显子插入到16号内含子中的异常转录,但 Western blot分析在同卵突变胚胎的心脏中并未发现相应蛋白。(来源:J:66242)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
11
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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