Exons 14和15,它们共同编码IIS5跨膜段和重复II中的孔,周围有loxP位点,随后在体外通过Cre介导的重组被剔除,然后传给下一代。尽管RT-PCR检测到13号外显子插入到16号内含子中的异常转录,但 Western blot分析在同卵突变胚胎的心脏中并未发现相应蛋白。(来源:J:66242)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count