通过Cre介导的重组,Fancatm1Wong中去除了含floxed neo cassette的元件,保留了1到6号外显子的IRES-NLS-lacZ序列。针对目标exons的转录未检测到,但纯合突变小鼠的RT-PCR结果显示存在14到18号外显子的转录。由于没有C端抗体,无法确定检测到的讯息是否产生了蛋白质。(来源:J:85108)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
2
10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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