Exon 2被替换为含有EGFP和floxed neo的 cassette,EGFP由内源性启动子和调节元件驱动表达。与内源性serpinb6atm1.1Pib的GFP表达相比,保留neo cassette确实增加了表达量。 Western blot结果显示,纯合突变脾和胸腺组织中未检测到正常蛋白。(来源:J:85039)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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