通过同源重组,将人类cDNA编码EGFR插入了内源性位置。下游插入了一个RSV-neo载体。在脑组织的RNA酶保护实验中检测到了人类转录本的内源性水平,但在骨和上皮组织中观察到了部分失活表达,可能与下游的neo载体有关。(来源:J:84870)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
插入
--
1
9
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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