原编码区域的70% (1.2kb)被替换了 neo cassette。通过 Western blot 分析和同源突变肾脏和大脑提取物的电泳迁移率测定,未检测到基因产物。(来源:J:84756)
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70% (1.2 kb) of the endogenous coding region was replaced with a neo cassette. Gene product was undetected by Western blot analysis and electrophoresis mobility shift assay of homozygous mutant kidney and brain extracts, respectively. (J:84756)