一段包含5、6和7号外显子的序列通过同源重组被PGK-neo基因替换。被删除区域编码了成熟蛋白的酶活性外分泌部分,包括了apyrase保守区域2到4。尽管在纯合突变小鼠中检测到了neo插入的3'转录本,但是apyrase活性和免疫反应都没有被发现。(来源:J:76092)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
1
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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