这项T(4;11)(Mllt3;9Mll)1Thr的基因重排被设计用来模拟人类的T(9;11)(p22;q23)染色体易位,这种易位是引发白血病关联的。通过同染色体Cre介导的重组,单个loxP位点在Mlltm1Thr和Mllt3tm2Thr基因内产生了这一重排。在突变小鼠的多种组织中,通过RT-PCR分析,我们检测到了包含Mll第8个外显子和Mllt3第b个外显子的融合转录本。(来源:J:68500)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv-Gpi1c
Targeted
易位
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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