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A transition point mutation (A to G) at position 572 resulted in a histidine to arginine missense mutation at codon 191 (H191R). The substitution disrupts the conserved Cys2His2 unit that tetrahedrally coordinates a zinc ion between the anitparallel beta sheet and alpha helix of the zinc finger. DNA binding is putatively disrupted by the interference of the tertiary structure of the N-terminal of zinc finger 3. A full length protein that assembles into higher order complexes is produced from this allele. (J:84569)