Exon 1被通过同源重组插入了诺姆西林选择座。在纯合突变小鼠的视网膜中,通过 Western blot 分析未检测到正常蛋白。(来源:J:54021)
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Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected in the retinas of homozygous mutant mice by Western blot analysis. (J:54021)