Hoxb1^tm6(cre)Mrc

An IRES-Cre cassette containing a neomycin selection gene flanked with frt sites was introduced into the 3' untranslated region downstream of the translational stop codon and upstream of the endogenous polyadenylation signal. Crossing with a flp deleter line to excise the neomycin resistance gene resulted in animals able to express Cre from the Hoxb1 locus without interfering with endogenous Hoxb1 activity. (J:84448)