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使用相同的靶向构建，金属硫蛋白I和II都受到了干扰。金属硫蛋白II的第二个外显子在起始密码子下游30bp的位置插入了pMC1NeoPA选择标记。对铜经腹腔注射诱导基因的同源纯合子肝脏mRNA进行Northern blot分析显示，转录被阻止。此外，这些动物的肝脏中未检测到蛋白质产物。(来源：J:14416)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
