一个新测序的cassette替换了编码第308到336位氨基酸的两个外显子。在纯合突变MEFs的 Western blot分析中未检测到正常蛋白(来源:J:80766)。
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A neo cassette replaced two exons encoding amino acids 308 through 336. Normal protein was undetected by Western blot analysis of homozygous mutant MEFs. (J:80766)