在WEC9.6细胞中,基因的编码区域被替换为一个PGK-puromycin抗性 cassette,这个细胞中Hist1h1c和Hist1he基因已经过修改。通过E7.5胚胎的DNA进行PCR检测,确认了同源重组的正确性。E10.5胚胎提取物的反相高效液相色谱结果显示没有基因产物存在。(来源:J:83954)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
STOCK 129/Sv and C57BL/6J and SJL
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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