使用WC1.16细胞,该基因的整个编码区域被替换为PGK-neo cassette,这些细胞已经携带了Hist1h1c的修改。仅使用了含有这两种基因表观修饰的ES细胞克隆来生成转基因小鼠。基因产物的缺失通过反相高效液相色谱进行了验证。(来源:J:83954)
Basic Information
STOCK 129/Sv and C57BL/6J and SJL
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count