将人类CD4序列插入到一个包含4.8KB人CD2启动子序列和5.5KB下游序列的CD2微基因 cassette中。建立了8个转基因品系,其中线313(插入转录本拷贝数在15到20个左右)被选中进行进一步的育种和研究。通过FACS分析,结果显示人类CD4在转基因T细胞中的表达率超过95%。(来源:J:131345)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(CBA/Ca x C57BL/10)F2
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插入
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1
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7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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