删除了启动子的3'端、编码L1和L2区域的外显子,以及编码EC域的5'段,然后用同源重组替换为抗羟氨苄青霉素抗性基因 cassette。通过对单倍体突变动物的粒细胞、巨噬细胞和树突状细胞的RNA进行RT-PCR分析,确认了基因表达的缺失。(来源:J:83995)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
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51

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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