删除了启动子的3'端、编码L1和L2区域的外显子,以及编码EC域的5'段,然后用同源重组替换为抗羟氨苄青霉素抗性基因 cassette。通过对单倍体突变动物的粒细胞、巨噬细胞和树突状细胞的RNA进行RT-PCR分析,确认了基因表达的缺失。(来源:J:83995)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count