从第2外显子到第8外显子的基因组片段通过同源重组被一个PGK-neo cassette替换。被删除区域编码了该蛋白的PH和SH2区域。通过Northern blot分析,杂合突变小鼠的脑 cerebellums中未检测到转录本。(来源:J:78931)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count