在基因的3'端替换了12kb的序列,通过同源重组插入了诺卡因抗性基因座。基因靶向事件导致了包括跨膜域在内的最后3个编码外显子的缺失。通过Western blot对肌肉微粒的分析,证实了纯合突变动物中基因表达的缺失。(来源:J:83126)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
8
23

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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