从7号到9号外显子被替换为一个单一的loxP位点,经过同源重组和Cre介导的剪切。删除区域编码了膜蛋白、可溶性和细胞外膜近端部分。FACS分析和血清检测结果显示,纯合突变小鼠中这两种膜结合蛋白和可溶性蛋白的量都不明显(来源:J:55526)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
BALB/cJ
Targeted
插入,基因内删除
--
1
--
112

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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