在两个编码外显子周围,通过同源重组插入了带有floxed PGK-neo cassette和单个loxP位点。通过转暂时表达Cre重组酶,对目标的ES细胞去除了PGK-neo cassette。这些突变动物体内带有2个编码外显子的loxP位点。(来源:J:82911)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count