在两个编码外显子周围,通过同源重组插入了带有floxed PGK-neo cassette和单个loxP位点。通过转暂时表达Cre重组酶,对目标的ES细胞去除了PGK-neo cassette。这些突变动物体内带有2个编码外显子的loxP位点。(来源:J:82911)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
6
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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