内源性EDA外显子,它能发生替代剪接,已被替换为经过点突变优化的floxed EDA外显子,以提升5'和3'的剪接位点。RNA酶保护和RT-PCR分析证实了constitutive EDA外显子的包含,结果显示在所有转基因小鼠各组织中,这个外显子被包含在99-100%的转录本中。(来源:J:84274)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
核苷酸替换
--
1
2
10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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