这个基因在经由同源重组,将lacZ-neo cassette插入到exon 2后被打乱了。在纯合突变小鼠中,通过北向 blot 分析脑 RNA,基因表达是缺失的。(来源:J:71826)
查看原文 参与反馈
The gene was disrupted by insertion of a lacZ-neo cassette into exon 2 via homologous recombination. Gene expression was absent in homozygous mutant mice as determined by Northern blot analysis of brain RNA. (J:71826)