Exon 2被通过同源重组插入的lacZ-neo cassette打断了。通过RT-PCR和 Western blot分析,无论是纯合雌性还是杂合雄性,都没有检测到蛋白质或转录本,尽管在突变小鼠中lacZ的表达得到了确认。(来源:J:82505)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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