Exon 3,它编码外源性受体域1(D1)的配体结合区域,通过同源重组插入了诺姆林选择标记。通过Northern blot在纯合突变小鼠中识别到了两种异常转录本。这两种转录本都不包含外源性结合区域的序列,因此不会与内源性配体结合。这个靶向载体还被电穿孔法导入了来自C57BL/6背景的ES细胞,产生了Pigrtm1Rast(J:57987)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
--
17

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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