这个基因通过将exon 1替换为链状的白喉毒素A(DTA)基因和一个可删除的诺卡霉素抗性基因元件实现了突变。exon 1的剪接位点位于诺卡霉素抗性元件的3'端。通过在正确靶向的ES细胞中短暂表达Cre重组酶,去除了可删除的诺卡霉素抗性元件,从而允许DTA基因的转录。(来源:J:71355)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Deletion, Insertion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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