在基因的转录反向插入了一个带有单个LoxP位点的EGFP报告基因,然后在内含子1。接着,内含子7插入了含一个LoxP位点的neo选择基因和胸腺嘧啶激酶启动子。通过Cre介导的生殖细胞重组,删除了2-7号外显子,将胸腺嘧啶激酶启动子靠近了EGFP基因,以激活其转录。(来源:J:69949)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
159

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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