内源性位点被替换成一个含floxed neo cassette的元件,随后是编码一个突变、截短的RAG2蛋白('核心'RAG2)的cDNA序列,该蛋白缺失了C端的144个氨基酸。之后,通过在靶向细胞中短暂表达cre重组酶,floxed neo cassette被移除。(来源:J:81837)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count