内源性位点被替换成一个含floxed neo cassette的元件,随后是编码一个突变、截短的RAG2蛋白('核心'RAG2)的cDNA序列,该蛋白缺失了C端的144个氨基酸。之后,通过在靶向细胞中短暂表达cre重组酶,floxed neo cassette被移除。(来源:J:81837)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
7
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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