一段包含2号外显子和邻近内含子序列的769bp片段通过同源重组被neo标记筛选 cassette替换。起始密码子位于删除区域。通过Northern blot和不同组织的RT-PCR分析,转录本未在纯合突变小鼠中检测到。蛋白缺失通过流式细胞术、Western blot和免疫染色分析得到证实。外围白细胞中未检测到S100A和S100A8蛋白。(来源:J:81642)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
39

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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