在11-13号外显子的两侧引入了LoxP位点,然后在13号外显子的反向转录方向插入了抗氨苄青霉素基因。对杂合子和纯合子突变体的RT-PCR分析显示,基因表达分别减少了大约55%和20%于野生型水平。这是一种功能减弱的等位基因。(来源:J:81402)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入
--
1
17
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部