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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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基因编辑小鼠
Apc
tm3Mmt
Alias:
Apc
neoR
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基础信息
表型特征
文献报道
在11-13号外显子的两侧引入了LoxP位点,然后在13号外显子的反向转录方向插入了抗氨苄青霉素基因。对杂合子和纯合子突变体的RT-PCR分析显示,基因表达分别减少了大约55%和20%于野生型水平。这是一种功能减弱的等位基因。(来源:J:81402)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
2449944
129X1/SvJ
Targeted
插入
--
1
17
3
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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