这种突变是一个D17Aus9位点的删除,通过将诺卡因/胸腺嘧啶激酶的选择性载体通过同源重组插入到D17Aus9位点,然后在ES细胞中进行辐射处理,并筛选出不再表达胸腺嘧啶激酶的细胞系。这些ES细胞随后被用来培育杂合鼠。突变的详细定位和断裂点信息可见于文献J:36910中的描述。(J:36910)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(BALB/cJ x 129S4/SvJae)F1
Radiation induced
删除
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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