整个包含人类AGT基因组序列的插入,其中在启动子的-6位有A到G的突变,通过同源重组插入到了Hprt位点。(这个变异已知与人类高血压有关。)RNA酶保护实验显示转录基因在肝脏、肾脏、大脑和主动脉中表达。此外,免疫组织化学分析和 Western blot 验证了转录基因在肾脏和血浆中的表达。(来源:J:81310)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部